Drug intelligence / Profile preview

dioscorea bulbifera

Development stage
Unknown
Lead developer
Guang'anmen Hospital
Administration
Oral
01

Overview

*Dioscorea bulbifera*, commonly known as airpotato yam or Huang Yaozi in Traditional Chinese Medicine (TCM), is a perennial vine in the yam family (Dioscoreaceae). It is traditionally utilized in China for the treatment of thyroid-related conditions, including goiter and hyperthyroidism, as well as for its anti-tumor and anti-inflammatory properties. The plant contains various bioactive compounds, most notably norditerpene lactones known as diosbulbins (such as diosbulbin B) and steroid sapogenins like diosgenin. While it exhibits anti-thyroid activity, its clinical use is carefully monitored due to potential dose-dependent hepatotoxicity associated with certain constituents. Research, including studies by Guang'anmen Hospital, focuses on evaluating the efficacy and safety of TCM prescriptions containing this botanical extract in managing hyperthyroidism symptoms and regulating thyroid hormone levels.

Other names
airpotato yamHuang Yaoziair potatobitter yampotato yamDioscorea bulbifera L.
02

Targets

15-LOX (Lysyl Oxidase)PfLDH (Plasmodium falciparum lactate dehydrogenase)

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