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DMSB01
- Development stage
- Unknown
- Lead developer
- Samyang Biopharmaceuticals
- Modality
- Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intradermal, Percutaneous
01
Overview
DMSB01 is an injectable, biodegradable liquid dermal filler composed of poly d-l-lactic acid (PDLLA) with a methoxy polyethylene glycol (mPEG) initiator. Developed to overcome the limitations of traditional polymer fillers, such as slow reconstruction and particle agglomeration, DMSB01 exhibits rapid gelation (within 5 minutes at body temperature) and high dispersion stability. Its mechanism of action involves the induction of M2 macrophages and the upregulation of Transforming Growth Factor beta (TGF-β), which stimulates the synthesis of Type I and Type III collagen. This process facilitates soft tissue volume restoration and the improvement of wrinkles, specifically targeting indications such as Crow's Feet lines and general skin photoaging.
- Other names
- PDLLA-mPEG fillerpoly d-l-lactic acid-methoxy polyethylene glycol filler
02
Targets
TGFB (GARP–latent transforming growth factor beta 1 complex)
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