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Drug intelligence / Profile preview
doxycycline + hydroxychloroquine + leflunomide + tofacitinib
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination therapy consisting of four medications used for the treatment of rheumatoid arthritis (RA). The combination includes doxycycline (an antibiotic), hydroxychloroquine (an antimalarial), leflunomide (a disease-modifying antirheumatic drug/DMARD), and tofacitinib (an oral Janus kinase inhibitor). This combination represents a multi-targeted approach to treating RA, with each component working through different mechanisms to reduce inflammation and disease activity.
02
Targets
DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)JAK1 (Janus kinase 1)JAK2 (Janus kinase 2)JAK3 (Janus kinase 3)TLR7 (Toll-like receptor 7)TLR9 (Toll-like receptor 9)TYK2 (Tyrosine kinase 2)MMP12 (Macrophage Metalloelastase)TLR (Toll-like receptors)
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