Drug intelligence / Profile preview

ELI-002

Development stage
Phase 2
Lead developer
Elicio Therapeutics
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Peptides, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

ELI-002 is an investigational cancer vaccine targeting cancers driven by mutations in the KRAS gene. It utilizes Amphiphile (AMP) technology and consists of AMP-modified mutant KRAS peptide antigens and an AMP-modified CpG oligodeoxynucleotide adjuvant (ELI-004). The vaccine is designed to target lymph nodes, enhancing immune cell activation and generating tumor-specific immune responses. The ELI-002 7P formulation targets seven common KRAS mutations: G12D, G12R, G12V, G12A, G12C, G12S, and G13D. Developed by Elicio Therapeutics, clinical data suggests ELI-002 induces strong mKRAS-specific T cell responses correlated with improved disease-free survival.

Brand names
ELI-002 7PELI002 7PELI 002 7P
Other names
AMP KRAS vaccine ELI-002
02

Targets

TLR9 (Toll-like receptor 9)pMHC-I (Peptide–MHC class I complex)

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