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epcoritamab + zanubrutinib + rituximab
- Development stage
- Unknown
- Lead developer
- AbbVie
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous, Oral, Intravenous
01
Overview
Epcoritamab + zanubrutinib + rituximab (EZR) is a chemotherapy-free combination regimen currently under investigation in a Phase 2 clinical trial (NCT06563596) for patients with relapsed or refractory follicular lymphoma (FL) or marginal zone lymphoma (MZL). The regimen is led by Dr. Reid Merryman at the Dana-Farber Cancer Institute. Epcoritamab is a bispecific antibody that binds to CD3 on T-cells and CD20 on B-cells, inducing T-cell-mediated killing of malignant B-cells. Zanubrutinib is a potent, selective Bruton tyrosine kinase (BTK) inhibitor that disrupts B-cell receptor signaling, while rituximab is a chimeric monoclonal antibody targeting CD20. This triple combination aims to achieve deep and durable remissions by simultaneously engaging the immune system and inhibiting key survival pathways in lymphoma cells.
- Brand names
- EpkinlyTepkinlyBrukinsaRituxanMabThera
- Other names
- EZR regimenEZR study
02
Targets
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