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ERI-0035

Development stage: Preclinical
Lead developer: Novatium Therapeutics
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

ERI-0035 is an allogeneic, universal CAR-T cell therapy being developed by Novatium in collaboration with Factor Bioscience. It is engineered to simultaneously target CD5 and B-cell maturation antigen (BCMA). This dual-targeting approach is designed to treat high-risk multiple myeloma (HrML) and systemic lupus erythematosus (SLE) by eliminating malignant plasma cells and autoreactive B-cell populations. As an allogeneic 'universal' therapy, it is derived from healthy donor cells rather than the patient's own, potentially allowing for off-the-shelf availability. The program is currently in the discovery to preclinical stages of development.

Other names: ERI-0035-Novatium-CD5-BCMA-Universal (allogeneic) CAR-T cell therapy-High-risk multiple myeloma (HrML)-Systemic lupus erythematosus (SLE)ERI-0035-Novatium-CD5-BCMA-Universal (allogeneic) CAR-T cell therapy

Targets

CD5 (T-cell surface glycoprotein CD5)BCMA (B-cell maturation antigen)

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