erianin

Erianin is a **natural small molecule bibenzyl derivative** isolated primarily from species of the Dendrobium genus (notably Dendrobium chrysotoxum and Dendrobium nobile), traditional Chinese medicinal herbs. It is structurally classified as 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol (C18H22O5). Erianin exhibits a range of **pharmacological effects including anti-tumor, anti-inflammatory, anti-angiogenic, anti-psoriatic, antiviral, and anti-diabetic retinopathy activity**. Its anticancer mechanisms include inhibition of cell proliferation, induction of apoptosis, cell cycle arrest, autophagy, ferroptosis, and inhibition of tumor angiogenesis and migration. It acts by modulating various signaling pathways such as PI3K/Akt, MEK/ERK, JNK, mTOR/p70S6K/4EBP1, JAK/STAT3, GSK3β, HIF-1α/PD-L1, and NLRP3/ROS. Erianin is a **direct inhibitor of the NLRP3 inflammasome** and also interacts with tubulin (antimitotic activity). It has shown therapeutic effects in preclinical models of multiple cancers (e.g. pancreatic, lung, breast, prostate, bladder, osteosarcoma), psoriasis, diabetic nephropathy/retinopathy, and various inflammatory conditions. Limitations for clinical application include **poor water solubility and bioavailability**, though synthetic modifications and derivatives are being explored to address these issues[1][2][3][4][5][6].

Other names

2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol95041-90-0