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erythropoietin
- Development stage
- Approved
- Lead developer
- Amgen
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
Erythropoietin is a glycoprotein hormone primarily produced by the kidneys that regulates red blood cell production (erythropoiesis) in response to hypoxia. Recombinant forms, such as epoetin alfa, are used therapeutically to treat anemia associated with chronic kidney disease, chemotherapy for non-myeloid malignancies, HIV therapy (zidovudine-induced anemia), and to reduce the need for allogeneic blood transfusions during certain surgeries. Mechanistically, erythropoietin binds to the erythropoietin receptor (EPO-R) on erythroid progenitor cells in bone marrow, activating JAK2/STAT5 signaling pathways that promote survival and differentiation of these cells into mature red blood cells[1][4][5]. The drug is administered via intravenous or subcutaneous injection.
- Brand names
- EpogenProcritEprexNeoRecormon
- Other names
- epoetin alfaepoetin betaepoetin zeta
02
Targets
Erythropoietin ReceptorJAK2 (Janus kinase 2)
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