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fecal microbiota transplantation + ruxolitinib + methylprednisolone
- Development stage
- Unknown
- Lead developer
- First Saint Petersburg State Medical University
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This combination therapy is being investigated as a first-line treatment for severe acute intestinal graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation. The regimen integrates three distinct therapeutic modalities: fecal microbiota transplantation (FMT) to restore gut microbial diversity and intestinal barrier integrity; ruxolitinib, a small molecule Janus kinase (JAK) 1/2 inhibitor that blocks pro-inflammatory cytokine signaling; and methylprednisolone, a standard-of-care glucocorticoid for broad immunosuppression. This multi-targeted approach aims to improve response rates in patients who typically show poor outcomes with steroid monotherapy. The clinical evaluation is led by St. Petersburg State Pavlov Medical University.
- Other names
- FMT + ruxolitinib + steroidsallogeneic fecal microbiota + ruxolitinib + methylprednisolone
02
Targets
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