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Fufang Danxiong Granules

Development stage: Phase 2
Lead developer: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Fufang Danxiong Granules (TDX105) is a traditional Chinese medicine (TCM) botanical formulation developed by the Cancer Hospital of the Chinese Academy of Medical Sciences. It is primarily being investigated for the prevention of regorafenib-induced dermatologic toxicities, specifically hand-foot skin reaction (HFSR), in patients with colorectal cancer. The formulation is a compound (Fufang) likely containing extracts of *Salvia miltiorrhiza* (Danshen) and *Ligusticum chuanxiong* (Chuanxiong), which are traditionally used to promote blood circulation and alleviate stasis. By improving local microcirculation and potentially exerting anti-inflammatory effects, TDX105 aims to reduce the severity of skin toxicities that often lead to dose reductions or treatment discontinuation of multi-kinase inhibitors like regorafenib.

Brand names: Danxiong particles
Other names: Compound Danxiong Granules

Targets

PIK3R1 (Phosphoinositide-3-kinase regulatory subunit 1)TP53 (Cellular Tumor Antigen p53 R175H)SFK (SRC family kinases)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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