Drug intelligence / Profile preview

golidocitinib + CHOP

Development stage
Unknown
Lead developer
Innovent Biologics
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Golidocitinib + CHOP is an investigational combination therapy consisting of golidocitinib, a selective Janus kinase 1 (JAK1) inhibitor, and the standard CHOP chemotherapy regimen. Golidocitinib is a small molecule developed for its targeted inhibition of JAK1, which plays a key role in cytokine signaling pathways involved in hematologic malignancies. The CHOP regimen includes cyclophosphamide (an alkylating agent), doxorubicin (an anthracycline), vincristine (a mitotic inhibitor), and prednisone (a corticosteroid). This combination is being explored primarily for the treatment of aggressive lymphomas such as peripheral T-cell lymphoma and diffuse large B-cell lymphoma.

Brand names
Xruida
Other names
Golidocitinib plus CHOPGolidocitinib + Cyclophosphamide + Doxorubicin + Vincristine + Prednisone
02

Targets

DNAJAK1 (Janus kinase 1)GR (Glucocorticoid receptor)TUBB (Tubulin (alpha and beta subunits))

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