Drug intelligence / Profile preview

Haoqin Qingdan Tang

Development stage
Unknown
Lead developer
China Academy of Chinese Medical Sciences
Administration
Oral
01

Overview

Haoqin Qingdan Tang (HQQDT), also known as Haoqin Qingdan Decoction, is a classic Traditional Chinese Medicine (TCM) multi-herb formula first recorded in the Qing-dynasty text *Chong Ding Tong Su Shang Han Lun* by Yu Genchu. It is traditionally used to clear damp-heat from the gallbladder and Shaoyang channel, making it a standard treatment for jaundice, cholecystitis, and viral infections. The formula typically consists of eight to eleven herbal components, including *Artemisia annua* (Qinghao), *Scutellaria baicalensis* (Huangqin), *Bambusa tuldoides* (Zhuru), *Pinellia ternata* (Banxia), *Citrus aurantium* (Zhiqiao), *Citrus reticulata* (Chenpi), *Poria cocos* (Fuling), and Biyu powder (talcum, licorice, and indigo). Modern pharmacological research has demonstrated that HQQDT possesses potent anti-inflammatory, immunomodulatory, and antiviral properties. It is being investigated for its therapeutic potential in cholestatic liver disease, influenza A, COVID-19, and as an immune-reconstitution therapy to enhance CD4+ T-cell recovery in HIV/AIDS patients.

Other names
Artemisia Annua and Scutellaria Decoction to Clear the GallbladderHao Qin Qing Dan TangHaoqin Qingdan DecoctionHaoqin Qingdan GranulesHQQDHQQDTSweet Wormwood and Scutellaria Decoction to Clear the GallbladderSweet Wormwood and Scutellaria Gallbladder-Clearing Decoction
02

Targets

JAK1 (Janus kinase 1)MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT1 (Signal transducer and activator of transcription protein 1)STAT2STAT3 (Signal Transducer and Activator of Transcription 3)TLR4 (Toll-like receptor 4)TLR7 (Toll-like receptor 7)ABCB1 (P-glycoprotein)ABCG2 (Breast cancer resistance protein)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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