Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
HinTCAR2019
- Development stage
- Unknown
- Lead developer
- Tongji Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
HinTCAR2019 is a hinge-optimized, tandem bispecific chimeric antigen receptor (CAR) T-cell therapy targeting both CD19 and CD20 antigens. Developed to address antigen escape in patients with relapsed or refractory B-cell lymphoma (r/r BCL), the construct features a minimal hinge optimization—specifically a short "AS" motif between the scFv and hinge domain—which enhances CAR surface expression and cytotoxic potency compared to earlier dual CAR constructs. Clinical data from a Phase Ia/Ib study (NCT05388695) indicates a favorable safety profile and durable efficacy, particularly when used in a sequential strategy followed by autologous stem cell transplantation (ASCT) consolidation.
- Other names
- tandem CD19/CD20 CAR-Thinge-optimized tandem CD19/CD20 CAR T-cell therapy
02
Targets
Beyond the preview
Go deeper on HinTCAR2019.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HinTCAR2019.