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hydroxychloroquine + quinacrine
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy of two antimalarial drugs used primarily for treating systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). This combination is particularly valuable when hydroxychloroquine monotherapy fails to achieve clinical remission. Quinacrine provides synergistic anti-inflammatory effects when combined with hydroxychloroquine and does not increase the risk of retinopathy, making it a safer option for long-term use.
- Other names
- hydroxychloroquine + quinacrinehydroxychloroquine + atabrine
02
Targets
BLM (BLM helicase)IFN-α (Interferon alpha-7)TLR (Toll-like receptors)TNFA (Tumor necrosis factor alpha (soluble))
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