Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
IL13Rα2-specific bispecific T-cell engager precomplexed with T cells
- Development stage
- Preclinical
- Lead developer
- Northwestern University Feinberg School of Medicine
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cell Therapies
- Administration
- Intrathecal
01
Overview
An investigational intrathecal cell-based immunotherapy in which naïve T cells are precomplexed with an IL13Rα2 × CD3 bispecific T-cell engager. The surface-bound engager retargets the administered T cells to IL13Rα2-expressing tumor cells and promotes CD3-mediated T-cell activation and cytotoxicity. In preclinical patient-derived xenograft models, this approach showed antitumor activity and survival benefit in glioblastoma and leptomeningeal disease models. The molecular identity of the bispecific engager and any sponsor-specific product identifier have not been publicly disclosed. (academic.oup.com)
- Other names
- IL13Rα2-specific bispecific T-cell engager precomplexed with T cellspBTE
02
Targets
CD3 (T-cell surface glycoprotein CD3)IL13RA2 (Interleukin-13 receptor subunit alpha 2)
Beyond the preview
Go deeper on IL13Rα2-specific bispecific T-cell engager precomplexed with T cells.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on IL13Rα2-specific bispecific T-cell engager precomplexed with T cells.