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investigational modulator
- Development stage
- Preclinical
- Lead developer
- Samsung Medical Center
- Modality
- Small Molecules
01
Overview
The investigational modulator (IM) is a novel small-molecule epigenetic modulator being evaluated for its potential to enhance the efficacy of CAR-T cell therapy in diffuse large B-cell lymphoma (DLBCL) [1503eP]. In preclinical studies, epigenetic priming with this modulator demonstrated dual-axis immunometabolic regulatory effects [1503eP]. In CD19 CAR-T cells, the modulator promotes central memory-associated phenotypes, reduces inhibitory receptor expression, and induces persistence-associated transcriptomic reprogramming [1503eP]. In DLBCL models, it induces calcium signaling alterations, mitochondrial stress responses, reactive oxygen species (ROS) modulation, and apoptosis-related signaling activation, thereby increasing lymphoma susceptibility and overcoming intrinsic resistance [1503eP].
- Other names
- IMnovel small-molecule modulator
02
Targets
AGER (RAGE)BACE1 (Beta-site APP-cleaving enzyme 1)JAK2 (Janus kinase 2)STAT1 (Signal transducer and activator of transcription protein 1)
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