itraconazole + piperacillin + tazobactam

This is a combination regimen consisting of three drugs:

• Itraconazole is a triazole antifungal agent that inhibits fungal cytochrome P450-dependent enzyme lanosterol 14α-demethylase, thereby impairing ergosterol synthesis and disrupting fungal cell membrane formation. It is used to treat various systemic and superficial fungal infections.
• Piperacillin is an extended-spectrum ureidopenicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
• Tazobactam is a β-lactamase inhibitor that protects piperacillin from enzymatic degradation by β-lactamases produced by certain bacteria, thus extending the antibacterial spectrum of piperacillin.

The combination of piperacillin and tazobactam (often known as Zosyn or Tazocin) is widely used for severe bacterial infections such as intra-abdominal infections, pneumonia, skin/soft tissue infections, gynecological infections, and sepsis. Itraconazole may be co-administered in cases where there are concurrent or suspected invasive fungal infections.