Drug intelligence / Profile preview

jingfang mixture

Development stage
Phase 4
Lead developer
Lunan Houpu Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Jingfang mixture is a traditional Chinese medicine (TCM) multi-herbal formulation used primarily for its anti-inflammatory and antithrombotic properties. It is derived from the classical prescription "Jingfang Baidu Power" and has been developed into various forms including granules. The formulation contains multiple active ingredients—network pharmacology studies have identified at least 159 compounds targeting over 276 proteins—with key components such as Ligusticum chuanxiong and Glycyrrhiza uralensis among others[1][3][7]. Mechanistically, it exerts effects by modulating inflammatory pathways including TNF signaling, NF-κB pathway, MAPK pathway, and downregulating phosphorylation of p38 MAPK and ERK1/2[1]. Preclinical studies show efficacy in reducing neuroinflammation after intracerebral hemorrhage[3], improving diabetic wound healing[9], treating thrombosis[4], relieving symptoms of wind-cold common cold syndromes (e.g., headache, aversion to cold)[6], and potentially supporting early pancreatic cancer therapy[5]. Its action is characterized by multi-component synergy acting on multiple targets relevant to inflammation and immune modulation.

Brand names
Jingfang MixtureJingfang GranulesJFG
Other names
Jingfang Baidu Power (original formula)Jing Fang MixtureJF
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)EGFR (Epidermal growth factor receptor)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)JAK2 (Janus kinase 2)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)STAT3 (Signal Transducer and Activator of Transcription 3)RK (Ribokinase)MAPK3 (Mitogen-activated protein kinase 1)MAPK14 (p38 mitogen-activated protein kinase alpha)TNFA (Tumor necrosis factor alpha (soluble))

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