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Jingfang mixture is a traditional Chinese medicine (TCM) multi-herbal formulation used primarily for its anti-inflammatory and antithrombotic properties. It is derived from the classical prescription "Jingfang Baidu Power" and has been developed into various forms including granules. The formulation contains multiple active ingredients—network pharmacology studies have identified at least 159 compounds targeting over 276 proteins—with key components such as Ligusticum chuanxiong and Glycyrrhiza uralensis among others[1][3][7]. Mechanistically, it exerts effects by modulating inflammatory pathways including TNF signaling, NF-κB pathway, MAPK pathway, and downregulating phosphorylation of p38 MAPK and ERK1/2[1]. Preclinical studies show efficacy in reducing neuroinflammation after intracerebral hemorrhage[3], improving diabetic wound healing[9], treating thrombosis[4], relieving symptoms of wind-cold common cold syndromes (e.g., headache, aversion to cold)[6], and potentially supporting early pancreatic cancer therapy[5]. Its action is characterized by multi-component synergy acting on multiple targets relevant to inflammation and immune modulation.
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