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LAM-Ce6
- Development stage
- Preclinical
- Lead developer
- Korea University
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**LAM-Ce6** is an experimental macrophage-targeted photoactivatable theranostic conjugate composed of the Dectin-1 ligand laminarin covalently linked to the near-infrared fluorescent photosensitizer chlorin e6. It is being investigated in atherosclerotic rabbit models as an intravascular imaging-guided phototherapy for inflamed, macrophage-rich atherosclerotic plaques. Laminarin targets Dectin-1-expressing macrophages, while laser activation of chlorin e6 generates local photodynamic effects that promote autophagy, macrophage apoptosis, MerTK-associated efferocytosis, inflammation resolution, and TGF-beta/CTGF-associated collagen-rich fibrotic plaque stabilization. LAM-Ce6 has been reported in preclinical studies using OCT-NIRF catheter imaging and has not been established as a clinical therapeutic product.
- Other names
- laminarin-Ce6laminarin-Ce-6laminarin-Ce 6laminarin-chlorin e6
02
Targets
CLEC7A (Dectin-1)
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