Lanzhou Univ. KRAS G12D compound 16k

Lanzhou Univ. KRAS G12D compound 16k: sourced facts only. name: "Herein, we report the discovery of 16k, a novel KRAS G12D inhibitor based on a 6-methoxyquinazoline scaffold, identified through the scaffold hopping and structural optimization strategies." [PMID:42001589]; target: "Herein, we report the discovery of 16k, a novel KRAS G12D inhibitor based on a 6-methoxyquinazoline scaffold, identified through the scaffold hopping and structural optimization strategies." [PMID:42001589]; developer: "School of Pharmacy, and State Key Laboratory of Natural Product Chemistry, Lanzhou University, Lanzhou 730000, China." [PMID:42001589]; stage: "The compound 16k exhibited significant antiproliferative effects against KRAS G12D mutant tumor cells, specifically the AGS and GP2D cell lines (IC50 = 0.18 and 0.21 μM, respectively), with minimal cytotoxicity toward normal cells and effectively inhibited colony formation." [PMID:42001589]