Drug intelligence / Profile preview

LBG-1600M

Development stage
Phase 1
Lead developer
Suzhou Longbotai Pharmaceutical
Modality
Small Molecules
Administration
Topical
01

Overview

LBG-1600M is a topical small molecule Janus kinase 1 (JAK1) inhibitor developed by Suzhou Longbotai Pharmaceutical for the treatment of atopic dermatitis. By selectively inhibiting the JAK1 enzyme, the drug modulates the signaling pathways of several pro-inflammatory cytokines, such as IL-4, IL-13, and IL-31, which are central to the pathogenesis of atopic dermatitis. This mechanism helps to reduce skin inflammation and alleviate pruritus. LBG-1600M is formulated as an ointment for topical application, designed to provide localized therapeutic effects while minimizing the systemic exposure and associated side effects often seen with oral JAK inhibitors.

02

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