leptin fragment

Leptin fragment (specifically the 35-amino-acid fragment aa22-56) is a peptide therapeutic being developed by Aderans in collaboration with Osaka University for the treatment of hair loss and the promotion of hair growth. Derived from the N-terminus of the adipokine leptin, this fragment acts as an anagen inducer in the hair follicle cycle. It mimics the activity of full-length leptin by binding to the leptin receptor, which stimulates the phosphorylation of extracellular signal-regulated kinase (ERK), Janus kinase 2 (JAK2), and signal transducer and activator of transcription 3 (STAT3) in keratinocytes. This signaling cascade promotes the transition of hair follicles from the telogen (resting) phase to the active anagen (growth) phase. The candidate is currently in preclinical development.

Other names

35-amino-acid leptin fragment35-amino-acid leptin fragment (aa22-56)aa22-56aa-22-56aa 22-56human leptin fragment (aa22-56)leptin fragment (aa22-56)