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Linkage Therapeutics alpha-synuclein intrabody

Development stage: Preclinical
Lead developer: Linkage Therapeutics
Modality: scFv Fragments → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics

Overview

Linkage Therapeutics, a subsidiary of the Neural Stem Cell Institute, is developing an alpha-synuclein-targeting intracellular antibody (intrabody) for the treatment of Parkinson's disease. The therapeutic is developed using the proprietary PTAP™ (Precision Protein Clearance) platform, which is designed to selectively target and clear disease-causing protein aggregates within cells. By operating intracellularly, this intrabody specifically binds to toxic alpha-synuclein species and promotes their degradation, addressing a primary driver of neurodegeneration in Parkinson's disease. The program is currently in the preclinical and IND-enabling stage of development.

Other names: alpha-synuclein-intrabodyLinkage Therapeutics Parkinson's disease programPTAP alpha-synuclein intrabodyalpha-synuclein intracellular antibody

Targets

SNCA (Alpha-synuclein)

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