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LT-010366
- Development stage
- Unknown
- Lead developer
- Leadingtac
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
LT-010366: sourced facts only. name: "We have developed LT-010366 as a first-in-class orally bioavailable KRAS G12D degrader with high potency and selectivity." [DOI:10.1158/1538-7445.am2025-1648]; target: "We have developed LT-010366 as a first-in-class orally bioavailable KRAS G12D degrader with high potency and selectivity." [DOI:10.1158/1538-7445.am2025-1648]; developer: "Leadingtac Pharmaceutical (Shaoxing) Co., Ltd, Shanghai, China." [DOI:10.1158/1538-7445.am2025-1648]; modality: "We have developed LT-010366 as a first-in-class orally bioavailable KRAS G12D degrader with high potency and selectivity." [DOI:10.1158/1538-7445.am2025-1648]; stage: "In CDX tumor, daily oral administration of LT-010366 exhibited potent antitumor activities in both PDAC (PK-59) and CRC (GP2D) models with KRAS G12D mutation, resulting in profound tumor regression without body weight loss." [DOI:10.1158/1538-7445.am2025-1648]
02
Targets
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