manzamine a

Manzamine A is a marine-derived, β-carboline-fused pentacyclic alkaloid found in several marine sponge genera, including Haliclona and Acanthostrongylophora. It demonstrates diverse biological activities, including anticancer, antimalarial, antiviral (notably against HSV-1 and HIV-1), anti-hyperlipidemic, anti-atherosclerotic, antimicrobial, and potential neuroprotective effects. Mechanistically, Manzamine A is known to inhibit Glycogen Synthase Kinase-3 (GSK-3), modulate SIX1 gene expression, disrupt autophagy by uncoupling vacuolar ATPases, and inhibit other proteins involved in cellular proliferation (e.g., JAK2, AKT, PKC, FAK, Bcl-2, IκB). It causes cell cycle arrest, suppresses the epithelial–mesenchymal transition, and can induce apoptosis in various cancer cell types. It is being actively investigated in preclinical and early-phase research for multiple therapeutic areas including cancer, Alzheimer’s disease, and infectious diseases[1][2][3][5][7][9].

Other names

Manzamine AKeramamine A104196-68-1CHEBI:66667