Drug intelligence / Profile preview

methylprednisolone + upadacitinib

Development stage
Preclinical
Lead developer
AbbVie
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular, Topical
01

Overview

A combination of methylprednisolone, a synthetic glucocorticoid corticosteroid, and upadacitinib (RINVOQ), a selective JAK1 inhibitor. This combination may have enhanced anti-inflammatory effects but also potentially increased immunosuppressive risks. Methylprednisolone acts through glucocorticoid receptor binding to reduce inflammation, while upadacitinib selectively inhibits JAK1 signaling to block inflammatory cytokine pathways.

02

Targets

GR (Glucocorticoid receptor)JAK1 (Janus kinase 1)

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