Drug intelligence / Profile preview

mometasone + probiotics

Development stage: Unknown
Lead developer: Organon
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Intranasal, Inhalation, Topical, Oral

Overview

A combination therapy consisting of mometasone furoate, a potent corticosteroid that reduces inflammation, and probiotics (typically containing beneficial bacteria such as bifidobacterium infantis and lactobacillus acidophilus). Mometasone works by decreasing inflammation through multiple mechanisms including reversing activation of inflammatory proteins, activating anti-inflammatory proteins, stabilizing cell membranes, and decreasing inflammatory cell influx. Probiotics are beneficial bacteria that support gut health.

Targets

PR (Progesterone receptor)CD209 (Dendritic cell-specific intercellular adhesion Molecule-3-Grabbing non-integrin)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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