Drug intelligence / Profile preview

mosunetuzumab + lenalidomide

Development stage
Phase 3
Lead developer
Genentech
Modality
T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

Mosunetuzumab + lenalidomide is an investigational combination therapy being evaluated for the treatment of follicular lymphoma. Mosunetuzumab is a CD20xCD3 bispecific antibody that redirects T cells to engage and eliminate malignant B cells, while lenalidomide is a potent immunomodulatory agent that can stop cancer cells from developing and help the immune system attack cancer cells. The combination is designed to provide synergistic effects in treating lymphoma, particularly in relapsed/refractory settings.

Other names
M+LenMosun+LenM-Len
02

Targets

CD20 (B-lymphocyte antigen CD20)CD3 (T-cell surface glycoprotein CD3)CRBN (Cereblon)

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