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Drug intelligence / Profile preview
NBT508
- Development stage
- Phase 1
- Lead developer
- New-Bio
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
NBT508 is a recombinant humanized bispecific antibody targeting CD20 and CD3, developed by Newport Biopharmaceutical Technology (Shanghai) Co., Ltd. for the treatment of B-cell non-Hodgkin lymphoma (B-NHL). By simultaneously binding to the CD20 antigen on the surface of malignant B cells and the CD3 receptor on T cells, NBT508 facilitates the formation of an immunological synapse, leading to T-cell activation and the subsequent directed lysis of the cancerous B cells. It is currently undergoing Phase 1 clinical evaluation in patients with relapsed or refractory B-cell malignancies.
02
Targets
B-cell antigen receptor complex-associated protein beta chainCD20 (B-lymphocyte antigen CD20)CD3 (T-cell surface glycoprotein CD3)
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