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nPT-ery
- Development stage
- Preclinical
- Lead developer
- GSK
- Modality
- RNA-Targeting Small Molecules → Nucleic Acid-Directed Small Molecules → Small Molecules
01
Overview
nPT-ery is a program comprising anti-inflammatory erythromycin analogues, developed by Biotica Technology in partnership with GSK. These compounds are macrolide antibiotics specifically engineered to treat inflammatory diseases by leveraging the anti-inflammatory and immunomodulatory actions of erythromycin, which are distinct from its antibacterial activity. The program aims to discover, develop, and commercialize novel erythromycin-based macrolides.
02
Targets
IL-6 (Interleukin 6)IL8 (C-X-C Motif Chemokine Ligand 8)DEL-1 (EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3))SELE (E-selectin)GHSR (Growth hormone secretagogue receptor)ICAM1 (Intercellular Adhesion Molecule 1)JAK2 (Janus kinase 2)MAPK14 (p38 mitogen-activated protein kinase alpha)NF-κBSELP (P-selectin)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)VCAM1 (Vascular cell adhesion molecule 1)
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