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NT-0300

Development stage: Preclinical
Lead developer: NeuBase Therapeutics
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics

Overview

NT-0300 is a preclinical-stage therapeutic developed by NeuBase Therapeutics targeting the mutated KRAS gene, specifically designed as an inhibitor of KRAS G12D and G12V mutations, which are common oncogenic drivers in various cancers. It leverages NeuBase's PATrOL platform, likely involving peptide-nucleic acid antisense oligonucleotides (PNAs) for precise genetic modulation to inhibit mutant KRAS function. The program aims to address unmet needs in KRAS-mutant neoplasms, including solid tumors.[1][3][13]

Targets

Kirsten rat sarcoma viral oncogene homolog mRNAKRAS (Kirsten rat sarcoma viral oncogene homolog)

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