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NTX-472
- Development stage
- Preclinical
- Lead developer
- Nutcracker Therapeutics
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Small Molecules, Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
NTX-472 is a preclinical, trispecific, mRNA-based immunotherapy developed for the treatment of B cell lymphoma. It encodes a multispecific antibody that simultaneously targets CD20, CD19, and CD47 antigens on B cells. The therapy is delivered as an mRNA nanoparticle formulation that instructs cells to produce the engineered protein in vivo. By engaging these three targets at once, NTX-472 aims to enhance tumor cell killing and overcome resistance mechanisms seen with monospecific antibodies (such as antigen downregulation). Preclinical studies have demonstrated rapid depletion of B cells without detectable binding to red blood cells, suggesting a favorable safety profile compared to other anti-CD47 therapies[2][3][4][6][7].
- Brand names
- NTX-472NTX472NTX 472
- Other names
- M-23032M23032M 23032
02
Targets
CD19 (B lymphocyte antigen CD19)CD20 (B-lymphocyte antigen CD20)CD47 (Cluster of Differentiation 47)
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