Drug intelligence / Profile preview

Oxycodone DART

Development stage
Preclinical
Lead developer
Lehigh Valley Technologies
Modality
Small Molecules
Administration
Oral
01

Overview

Oxycodone DART is an abuse-resistant formulation of the opioid agonist oxycodone, developed by Lehigh Valley Technologies using its proprietary Diversion and Abuse Resistant Technologies (DART) platform. As a small molecule analgesic, oxycodone acts primarily as an agonist at the mu-opioid receptor (OPRM1) within the central nervous system, effectively managing moderate to severe pain. The DART technology is engineered to provide physical and chemical barriers that deter common methods of tampering and abuse, such as crushing for insufflation or extraction for intravenous injection. This formulation aims to maintain the therapeutic benefits of oxycodone while reducing the potential for non-medical use and diversion, addressing a critical need in the pain management landscape.

Other names
Oxycodone (abuse-resistant/DART)oxycodone DART abuse-resistant formulation
02

Targets

KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)

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