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polatuzumab vedotin + rituximab + cyclophosphamide + doxorubicin + zanubrutinib
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial People's Hospital
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Pola-ZRCHP is an investigational chemoimmunotherapy combination regimen being evaluated for the treatment of previously untreated diffuse large B-cell lymphoma (DLBCL), specifically targeting high-risk molecular subtypes such as MCD, BN2, and N1. The regimen builds upon the Pola-R-CHP backbone (polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone) by adding zanubrutinib, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor. Polatuzumab vedotin is an antibody-drug conjugate (ADC) targeting CD79b, delivering the microtubule inhibitor monomethyl auristatin E (MMAE). Rituximab is an anti-CD20 monoclonal antibody. Cyclophosphamide and doxorubicin are standard cytotoxic chemotherapy agents. The addition of zanubrutinib aims to enhance efficacy by inhibiting B-cell receptor signaling, which is often constitutively active in specific DLBCL subtypes.
- Other names
- Polatuzumab Vedotin in Combination With Zanubrutinib, Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone
02
Targets
BTK (Bruton tyrosine kinase)CD20 (B-lymphocyte antigen CD20)B-cell antigen receptor complex-associated protein beta chainDNATOP2A (DNA topoisomerase II)
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