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polatuzumab vedotin + zuberitamab + cyclophosphamide + doxorubicin + prednisone + orelabrutinib
- Development stage
- Unknown
- Lead developer
- InnoCare Pharma
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
POLA-Hi-CHP + orelabrutinib is an investigational chemoimmunotherapy combination regimen being evaluated for the treatment of the MCD subtype of diffuse large B-cell lymphoma (DLBCL). The regimen consists of the antibody-drug conjugate **polatuzumab vedotin** (targeting CD79b), the anti-CD20 monoclonal antibody **zuberitamab**, the chemotherapy agents **cyclophosphamide** and **doxorubicin**, the corticosteroid **prednisone**, and the small-molecule Bruton's tyrosine kinase (BTK) inhibitor **orelabrutinib**. This combination targets multiple pathways in B-cell malignancies, including B-cell receptor signaling and direct cytotoxic effects. It is specifically studied in the MCD subtype (defined by MYD88 and CD79B mutations), which often shows sensitivity to BTK inhibition. The regimen is typically administered as induction therapy followed by orelabrutinib monotherapy maintenance.
- Brand names
- PolivyAnshidaObritinib
- Other names
- VepoliximabPola-Hi-CHP-OPola-Hi-CHP plus orelabrutinib
02
Targets
CD20 (B-lymphocyte antigen CD20)BTK (Bruton tyrosine kinase)B-cell antigen receptor complex-associated protein beta chainTOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))
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