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protoporphyrin IX-loaded PESDA microbubbles
- Development stage
- Preclinical
- Lead developer
- Islamic Azad University
- Modality
- Small Molecules, Acoustic/Optical: Sonoporation, laser photoporation → Physical Methods → Gene Addition/Replacement → Gene Therapies
- Administration
- Intravenous
01
Overview
**Protoporphyrin IX-loaded PESDA microbubbles** are an investigational ultrasound-responsive formulation in which the sonosensitizer protoporphyrin IX is loaded into PESDA microbubbles composed of perfluorocarbon-exposed sonicated dextrose albumin. The formulation has been evaluated in animal models of atherosclerosis, neointimal hyperplasia, and restenosis together with low-level focused ultrasound or shock-wave exposure. Ultrasound-induced microbubble cavitation and sonoporation are intended to enhance local delivery and activation of protoporphyrin IX, generating oxidative stress and anti-inflammatory effects that reduce macrophage-derived foam cells and vascular smooth-muscle-cell hyperplasia. It is an experimental preclinical formulation and is not an approved medicinal product.
- Other names
- PpIX-loaded PESDA microbubblesprotoporphyrin IX-loaded perfluorocarbon-exposed sonicated dextrose albumin microbubbles
02
Targets
TSPO (Translocator Protein (18 kDa))
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