Drug intelligence / Profile preview

Qili Qiangxin capsules

Development stage: Unknown
Lead developer: Yiling Pharmaceutical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Qili Qiangxin capsules is a traditional Chinese medicine (TCM) formulation developed by Shijiazhuang Yiling Pharmaceutical for the treatment of chronic heart failure. Formulated under the guidance of the TCM collateral disease theory, it consists of a standardized extract of 11 medicinal herbs: Astragali Radix, Ginseng Radix et Rhizoma, Aconiti Lateralis Radix Preparata, Salvia miltiorrhiza Radix et Rhizoma, Descurainiae Semen lepidii Semen, Alismatis Rhizoma, Polygonati Odorati Rhizoma, Cinnamomi Ramulus, Carthami Flos, Periplocae Cortex, and Citri Reticulatae Pericarpium. Qili Qiangxin capsules exert cardioprotective effects through multiple mechanisms, including enhancing myocardial contractility, promoting diuresis, inhibiting the renin-angiotensin-aldosterone system (RAAS), reducing myocardial apoptosis and fibrosis, and improving energy metabolism.

Brand names: Qili QiangxinQili Qiangxin capsules
Other names: QLQXQQCQili Qiangxin capsuleQiliqiangxinQiliqiangxin capsuleQiliqiangxin capsules

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ATP1A1 (Sodium/potassium-transporting ATPase subunit alpha-1)SCN5A (Sodium channel protein type 5 subunit alpha)JAK2 (Janus kinase 2)JUN (Transcription factor Jun)MDM2 (Mouse double minute 2 homolog)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)RXRA (Retinoid X receptor alpha)STAT3 (Signal Transducer and Activator of Transcription 3)TP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)

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