Drug intelligence / Profile preview

qingjin huatan tang

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Qingjin Huatan Tang is a classic traditional Chinese medicine (TCM) prescription originating from the Ming Dynasty and documented in ancient medical texts such as "Yifang Kao" and "Genera Principles of Medicine"[3][6]. It is primarily used to treat respiratory diseases characterized by phlegm-heat obstructing the lungs, including cough with thick yellow phlegm, wheezing, chest tightness, shortness of breath, and related symptoms[6][7]. The formula works by clearing heat from the lungs, resolving phlegm, regulating qi (vital energy), stopping coughs, and supporting respiratory health[2][6]. Pharmacological studies have shown that Qingjin Huatan Tang exerts anti-inflammatory effects by downregulating inflammatory signaling pathways (such as JAK/STAT), suppressing TLR4 and MUC5AC expression in airway tissues, reducing mucus hypersecretion and airway inflammation[3][4]. Key bioactive components identified include meranzin (from bitter orange), baicalin/baicalein/wogonoside (from Scutellaria), which contribute to its anti-inflammatory activity[5]. The formula typically contains multiple herbs such as Trichosanthes seed (Gua Lou Ren), Pinellia rhizome (Zhi Ban Xia), Arisaema bile-cured rhizome (Dan Nan Xing), Chinese skullcap root (Huang Qin/Scutellaria baicalensis), Tangerine peel (Chen Pi), Apricot seed (Ku Xing Ren/Xing Ren), Bitter orange young fruit (Zhi Shi/Citrus aurantium immaturus) and Poria sclerotium (Fu Ling)[2][6]. Qingjin Huatan Tang is widely used for conditions like stable chronic obstructive pulmonary disease (COPD)[4], community-acquired pneumonia[3], acute/chronic bronchitis[6], upper respiratory tract infections[7], tonsillitis[7], acute lung injury[3]—especially when these are associated with phlegm-heat syndrome.

Brand names
Qing Jin Hua Tan WanQing Jin Hua Tan TangQJHTTQJHTD
Other names
清金化痰汤Qing Jin Hua Tan Decoction
02

Targets

JAK2 (Janus kinase 2)STAT3 (Signal Transducer and Activator of Transcription 3)STAT1 (Signal transducer and activator of transcription protein 1)TLR4 (Toll-like receptor 4)

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