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R-mini-CHOP
- Development stage
- Unknown
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous, Oral
01
Overview
R-mini-CHOP is a combination chemotherapy regimen consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (or prednisone). It is a modified version of the standard R-CHOP protocol with reduced doses of each component. The regimen was specifically developed for elderly patients (typically over 80 years old) or those with significant comorbidities who are ineligible for full-dose chemotherapy.
- Brand names
- R-mini-CHOP
- Other names
- mini-R-CHOPreduced-dose R-CHOPlow-dose R-CHOPminiCHOP
02
Targets
CD20 (B-lymphocyte antigen CD20)TOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))
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