recombinant human type XVII collagen microneedle patch

The recombinant human type XVII collagen microneedle patch is an investigational biologic therapy designed for the treatment of refractory or non-healing burn wounds, particularly in pediatric patients. Type XVII collagen (COL17A1) is a critical transmembrane protein and a structural component of hemidesmosomes, which are essential for anchoring the epidermis to the underlying dermis. Beyond its structural role, COL17A1 is vital for maintaining the niche of epidermal stem cells and hair follicle stem cells, and it plays a key role in regulating re-epithelialization and skin regeneration. The microneedle patch delivery system is engineered to penetrate the stratum corneum, delivering the recombinant collagen directly into the viable layers of the skin to promote wound closure and tissue repair in wounds that have failed to heal with standard treatments.