RELTpep-KLA exosomes

**RELTpep-KLA exosomes** are an experimental, mesenchymal stem cell-derived exosome therapy engineered for targeted cancer treatment. The extracellular vesicles are loaded with KRAS-targeting small interfering RNA and surface-modified with RELTpep-KLA, a hybrid peptide comprising the RELT-binding sequence CRQTKN and the proapoptotic mitochondrial membrane-disrupting peptide KLAKLAKKLAKLAK. The construct is designed to bind receptor expressed in lymphoid tissues on tumor cells, deliver KRAS siRNA, reduce ERK phosphorylation, and induce tumor-cell cytotoxicity. In reported preclinical studies, intravenously administered RELTpep-KLA-targeted, KRAS siRNA-loaded MSC exosomes inhibited growth of Panc-1 pancreatic tumor xenografts and showed activity in A549 lung tumor and Panc-1 pancreatic tumor cells. ([aacrjournals.org](https://aacrjournals.org/cancerres/article/84/6_Supplement/5748/740082/Abstract-5748-Inhibition-of-tumor-growth-using))

Other names

RELTpep-KLA exosomesRELTpep-KLA-targeted and KRAS siRNA-loaded MSC-exosomes