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rhodiola rosea
- Development stage
- Unknown
- Lead developer
- Zhongshan Hospital, Fudan University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Rhodiola rosea is a botanical extract derived from the root of the Rhodiola rosea plant, traditionally used in Chinese and Tibetan medicine as an adaptogen. It contains bioactive compounds such as salidroside and rosavins, which are thought to exert neuroprotective, antioxidant, and anti-inflammatory effects. In clinical research, it is being investigated for its potential to improve outcomes in patients with acute cerebral lacunar infarction, cerebral small vessel disease, and cognitive impairment, as well as an adjunct therapy for pulmonary tuberculosis. A Phase 4 trial in China specifically evaluates its efficacy in elderly patients with lacunar infarction compared to butylphthalide soft capsules.
- Other names
- Hong Jing Tianarctic rootgolden rootroserootking's crown
02
Targets
ABCB1 (P-glycoprotein)GR (Glucocorticoid receptor)CYP3A4 (Cytochrome P450 3A4)MAOB (Monoamine oxidase B)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)MAOA (Monoamine oxidase A)HSP70 (Heat shock protein 70)
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