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A combination therapy consisting of rituximab and omalizumab used primarily for treating refractory bullous pemphigoid. Rituximab is a monoclonal anti-CD20 antibody that depletes B cells, while omalizumab is an IgE-neutralizing antibody that prevents IgE from binding to its receptors on inflammatory cells. The combination appears to work synergistically, with studies showing a 70% durable complete response rate in bullous pemphigoid patients who failed conventional therapies.
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