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rituximab + recombinant human thrombopoietin
- Development stage
- Phase 3
- Lead developer
- Qilu Hospital of Shandong University
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
A combination therapy consisting of rituximab, a chimeric monoclonal antibody targeting CD20 on B cells, and recombinant human thrombopoietin (rhTPO), a thrombopoietin receptor agonist. This combination works through complementary mechanisms - rituximab depletes B cells and reduces autoantibody production that causes platelet destruction, while rhTPO stimulates platelet production by binding to the thrombopoietin receptor and activating the JAK2/STAT5 pathway. The combination has shown superior efficacy compared to rituximab monotherapy in treating immune thrombocytopenia (ITP), with higher complete response rates (45.4% vs 23.7%) and significantly shorter time to response (median 7 days vs 28 days).
- Brand names
- TPIAOMabThera
- Other names
- rhTPO + rituximabrituximab + rhTPOTPO-RA + rituximab
02
Targets
CD20 (B-lymphocyte antigen CD20)TPOR (Thrombopoietin receptor)
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