RM-041

RM-041: sourced facts only. name: "RM-041 is a potent and selective covalent inhibitor of KRASG13C(ON) with attractive drug-like properties." [DOI:10.1158/1538-7445.am2022-3598]; target: "RM-041 is a potent and selective covalent inhibitor of KRASG13C(ON) with attractive drug-like properties." [DOI:10.1158/1538-7445.am2022-3598]; developer: "1Revolution Medicines, Redwood City, CA." [DOI:10.1158/1538-7445.am2022-3598]; modality: "We report the development of a potent, selective, orally bioavailable tri-complex inhibitor of KRASG13C." [DOI:10.1158/1538-7445.am2022-3598]; stage: "In KRASG13C xenograft tumor models, oral administration of RM-041 produces deep and durable suppression of RAS pathway activity and induces tumor regressions in vivo at well-tolerated doses." [DOI:10.1158/1538-7445.am2022-3598]