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Ruanjian Qingmai Recipe
- Development stage
- Preclinical
- Lead developer
- Shanghai Hospital of Integrated Traditional Chinese and Western Medicine
- Administration
- Oral
01
Overview
Ruanjian Qingmai Recipe is a Traditional Chinese Medicine (TCM) herbal formula developed by the Shanghai Hospital of Integrated Traditional Chinese and Western Medicine for the treatment of lower extremity arteriosclerosis obliterans (ASO). The recipe is formulated based on TCM principles to "soften hardness" and "clear the vessels," targeting the atherosclerotic plaques and vascular inflammation associated with ASO. Clinical and mechanistic research suggests that the formula may exert its therapeutic effects by modulating the gut microbiota and influencing systemic metabolism, thereby improving peripheral circulation and alleviating ischemic symptoms.
- Other names
- Ruanjian Qingmai Decoction软坚清脉方
02
Targets
JAK2 (Janus kinase 2)STAT3 (Signal Transducer and Activator of Transcription 3)IL-17A (Interleukin-17A)CYP7A1 (Cholesterol 7alpha-hydroxylase)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IGF-1R (Insulin-like growth factor 1 receptor)IL21 (Interleukin-21)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)VEGFA (Vascular endothelial growth factor A)
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