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Shi-Yang-Xiao lotion

Development stage: Preclinical
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration: Topical

Overview

Shi-Yang-Xiao lotion is a **topically applied traditional Chinese medicine (TCM) formula** widely used for the treatment of **perianal eczema**. It is known for its potent **anti-inflammatory and antipruritic properties**, demonstrating **clinical efficacy in alleviating eczema-like skin lesions**. SYXL comprises multiple herbal compounds (UPLC-QTOF-MS/MS identified 93 compounds), but the precise full composition is not standardized in Western pharmacopeia. The **mechanism of action** centers on suppression of pro-inflammatory cytokines and inhibition of the **JAK2/STAT3 signaling pathway**, which translates to repair of the skin barrier, reduction of inflammation, and decrease in cytokines such as interleukin-1β, interleukin-6, and TNF-α.

Brand names: Shi-Yang-Xiao
Other names: SYXLShi-Yang-Xiao lotion

Targets

JAK2 (Janus kinase 2)STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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