Sigesbeckia pubescens Makino extract

Sigesbeckia pubescens Makino extract is derived from the aerial parts of the annual plant Sigesbeckia pubescens, a member of the Asteraceae family native to East Asia. It has a long history in traditional Chinese and Korean medicine for treating inflammatory conditions such as arthritis, rheumatic pain, backache, sciatica, hypertension, malaria, and neurasthenia[1][3][4][5]. The primary bioactive constituents include diterpenoids (notably kirenol derivatives), flavonoids, sesquiterpenoids, and triterpenoids[3]. Modern research demonstrates anti-inflammatory and analgesic effects through modulation of immune responses (cellular/humoral/nonspecific immunity) and cytokine production[1][3]. Mechanistically, it inhibits proinflammatory chemokine production by modulating the Janus kinase 2/signal transducer and activator of transcription proteins 1/3 (JAK2/STAT1/STAT3) pathway in skin cells[4][6], supporting its use for musculoskeletal diseases as well as atopic dermatitis. In the UK it is licensed as an over-the-counter herbal medicine for joint/muscle pain; in the US it is available as a dietary supplement for joint health[1].

Brand names

Phynova Joint and Muscle Pain Relief Tablets

Other names

Sigesbeckia pubescens extractSigesbeckia orientalis subsp. pubescens extractSt Paul’s wortXi Xian Caopig pungent weed