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sodium tungstate
- Development stage
- Phase 2
- Lead developer
- OXOLIFE
- Modality
- Small Molecules
- Administration
- Oral, Topical
01
Overview
Sodium tungstate is an inorganic salt that has been investigated for metabolic disorders and, more recently, for reproductive medicine. Historically, it was explored as a treatment for obesity and type 2 diabetes due to its insulin-mimetic properties and its ability to inhibit protein tyrosine phosphatases, which are involved in insulin signaling. However, a Phase II proof-of-concept trial (NCT00555074) conducted by the Hospital Clínic de Barcelona failed to demonstrate significant weight loss in obese patients. Currently, the Spanish biotechnology company Oxolife is developing a specific oral formulation of sodium tungstate, designated OXO-001, to improve pregnancy rates in women undergoing assisted reproductive technology (ART). OXO-001 is designed to enhance endometrial receptivity and facilitate embryo implantation, and it is currently in Phase II clinical development for use in patients undergoing IVF or ICSI.
- Brand names
- OXO-001OXO001OXO 001
- Other names
- sodium tungstate dihydratetungstic acid sodium salt
02
Targets
JAK2 (Janus kinase 2)STAT3 (Signal Transducer and Activator of Transcription 3)
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