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Sunflower oleodistillate + desonide is a combination of two active ingredients used in dermatology. Sunflower oleodistillate (SOD) is obtained through molecular distillation of sunflower oil without solvents, resulting in a concentrate with a 10-fold higher unsaponifiable fraction than natural sunflower oil. SOD has been shown to increase epidermal key lipid synthesis, reduce inflammation, and activate peroxisome proliferative-activated receptor-alpha (PPAR-alpha) in vitro. Desonide is a low-potency topical corticosteroid that works by activating natural substances in the skin to reduce swelling, redness, and itching. The combination leverages SOD's barrier-enhancing and anti-inflammatory properties with desonide's anti-inflammatory effects, potentially allowing for reduced steroid use in treating skin conditions like atopic dermatitis.
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